LANGERHAN CELL HISTIOCYTOSIS

Tennis Rackets



Langerhan cells are specialized macrophages that live in the skin. Their job is to be the first WBCs to spot pathogens invading the skin, then present their Ag to naive T cells. 


Langerhan Cell Histiocytosis is cancer of the Langerhan cells. There are a bunch of subtypes, and there’s seemingly a million details, but all you really need to know is what I bolded. This is a very buzzword-y disease. 



Birbeck Granules






I found the nomenclature of macrophages to be really confusing. 

I was thrown off by the vocabulary, like what exactly are monocytes, Langerhans cells, epithelioid cells and giant cells?

Well here's a nifty chart, I hope this helps.